Publications

2021

Otto Stern’s Legacy in Quantum Optics: Matter Waves and Deflectometry
S. Gerlich, Y. Y. Fein, A. Shayeghi, V. Köhler, M. Mayor, M. Arndt*
Molecular Beams in Physics and Chemistry (Eds. B. Friedrich, H. Schmidt-Böcking),  Springer, Cham. , 2021, pp. 547-573


2020

Matterwave interference and deflection of tripeptides decorated with fluorinated alkyl chains
J. Schätti, V. Köhler, M. Mayor, Y. Y. Fein, P. Geyer, L. Mairhofer, S. Gerlich, M. Arndt*
J. Mass Spectrom. 2020, 55, e4514


2019

Neutralization of insulin by photocleavage under high vacuum
J. Schätti, M. Kriegleder, M. Debiossac, M. Kerschbaum, P. Geyer, M. Mayor, M. Arndt*, V. Köhler*
Chem. Commun. 2019, 55, 12507-12510


2018

Artificial Metalloenzymes: Reaction Scope and Optimization Strategies
F. Schwizer, Y. Okamoto, T. Heinisch, Y. Gu, M. M. Pellizzoni, V. Lebrun, R. Reuter, V. Köhler, J. C. Lewis*, T. R. Ward*
Chem. Rev. 2018, 118, 142-231

Pushing the mass limit for intact launch and photoionization of large neutral biopolymers
J. Schätti, P. Rieser, U. Sezer, G. Richter, P. Geyer, G. G. Rondina, D. Häussinger, M. Mayor, A. Shayeghi, V. Köhler*, M. Arndt*
Commun. Chem. 2018, 1, 93

Tailored photocleavable peptides: fragmentation and neutralization pathways in high vacuum
M. Debiossac, J. Schätti, M. Kriegleder, P. Geyer, A. Shayeghi, M. Mayor, M. Arndt*, V. Köhler*
Phys. Chem. Chem. Phys. 2018, 20, 11412-11417


2017

Tailoring the volatility and stability of oligopeptides
J. Schätti, U. Sezer, S. Pedalino, J. Cotter, M. Arndt*, M. Mayor, V. Köhler*
J. Mass Spectrom. 2017, 52, 550-556


2016

An NAD(P)H-dependent artificial transfer hydrogenase for multienzymatic cascades
Y. Okamoto, V. Köhler, T. R. Ward*
J. Am. Chem. Soc. 2016, 138, 5781-5784

Efficient in situ regeneration of NADH mimics by an artificial metalloenzyme
Y. Okamoto, V. Köhler, C. E. Paul, F. Hollmann, T. R. Ward*
ACS Catal. 2016, 6, 3553-3557

Upregulation of an artificial zymogen by proteolysis
Z. Liu, V. Lebrun, T. Kitanosono, H. Mallin, V. Köhler, D. Häussinger, D. Hilvert, S. Kobayashi, T. R. Ward*
Angew. Chem. Int. Ed. 2016, 55, 11587-11590

Cascade Reactions
M. Dürrenberger, V. Köhler, Y. M. Wilson, D. Ghislieri, L. Knörr, N. J. Turner, T. R. Ward
Practical Methods for Biocatalysis and Biotransformations 3 (Eds. J. Whittall, P. W. Sutton, W. Kroutil),  J. Wiley & Sons Ltd., Chichester, 2016, pp. 213-252


Artificial metalloenzymes for the diastereoselective reduction of NAD+ to NAD2H
T. Quinto, D. Häussinger, V. Köhler, T. R. Ward*
Org. Biomol. Chem. 2015, 13, 357-360

Artificial concurrent catalytic processes involving enzymes
V. Köhler*, N. J. Turner*
Chem. Commun. 2015, 51, 450-464

Improving the catalytic performance of an artificial metalloenzyme by computational design
T. Heinisch, M. Pellizzoni, M. Dürrenberger, C. E. Tinberg, V. Köhler, J. Klehr, D. Häussinger, D. Baker*, T. R. Ward*
J. Am. Chem. Soc. 2015, 137, 10414-10419


2014

Expanding the chemical diversity in artificial imine reductases based on the biotin–streptavidin technology
T. Quinto, F. Schwizer, J. M. Zimbron, A. Morina, V. Köhler, T. R. Ward*
ChemCatChem 2014, 6, 1010-1014

Recent trends in biomimetic NADH regeneration
T. Quinto, V. Köhler, T. R. Ward*
Top. Catal. 2014, 57, 321-331

An artificial imine reductase based on the ribonuclease S scaffold
M. Genz, V. Köhler, M. Krauss, D. Singer, R. Hoffmann, T. R. Ward, N. Sträter*
ChemCatChem 2014, 6, 736-740


2013

Genetic optimization of the catalytic efficiency of artificial imine reductases based on biotin–streptavidin technology
F. Schwizer, V. Köhler, M. Dürrenberger, L. Knörr, T. R. Ward*
ACS Catal. 2013, 3, 1752-1755

Synthetic cascades are enabled by combining biocatalysts with artificial metalloenzymes
V. Köhler, Y. Wilson, M. Dürrenberger, D. Ghislieri, E. Churakova, T. Quinto, L. Knörr, D. Häussinger, F. Hollmann*, N. Turner*, T. R. Ward*
Nat. Chem. 2013, 5, 93-99


2012

Selective Oxidation
V. Köhler, B. Groenendaal, K. R. Bailey, A. Znabet, J. Raferty, M. Helliwell, N. J. Turner, K. Geitner, U. T. Bornscheuer, G. de Gonzalo
Practical Methods for Biocatalysis and Biotransformations 2 (Eds. J. Whittall, P. W. Sutton), J. Wiley & Sons Ltd., Chichester, 2012, pp. 181-202


2011

Chimeric self-sufficient P450cam-RhFRed biocatalysts with broad substrate scope
A. Robin, V. Köhler, A. Jones, A. Ali, P. P. Kelly, E. O'Reilly, N. J. Turner, S. L. Flitsch*
Beilstein J. Org. Chem. 2011, 7, 1494-1498

Cytochromes P450 as useful biocatalysts: addressing the limitations
E. O'Reilly, V. Köhler, S. L. Flitsch*,  N. J. Turner*
Chem. Commun. 2011, 47, 2490-2501

OsO4⋅ Streptavidin: A Tunable Hybrid Catalyst for the Enantioselective cis‐Dihydroxylation of Olefins
V. Köhler, J. Mao, T. Heinisch, A. Pordea, A. Sardo, Y. M. Wilson, L. Knörr, M. Creus, J. C. Prost, T. Schirmer*, T. R. Ward*
Angew. Chem. Int. Ed. 2011, 50, 10863-10866


2010

Highly stereoselective synthesis of substituted prolyl peptides using a combination of biocatalytic desymmetrization and multicomponent reactions
A. Znabet, E. Ruijter, F. J. de Kanter, V. Köhler, M. Helliwell, N. J. Turner, R. V. Orru*
Angew. Chem. Int. Ed. 2010, 49, 5289-5292

Protein-based hybrid catalysts — design and evolution
V. Köhler, Y. M. Wilson, C. Lo, A. Sardo, T. R. Ward*
Curr. Opin. Biotechnol. 2010, 21, 744-752

Enantioselective biocatalytic oxidative desymmetrization of substituted pyrrolidines
V. Köhler, K. R. Bailey, A. Znabet, J. Raftery, M. Helliwell, N. J. Turner*
Angew. Chem. Int. Ed. 2010, 49, 2182-2184


2008

Chiral boron‐bridged bisoxazoline (Borabox) ligands: Structures and reactivities of Pd and Cu complexes
V. Köhler, C. Mazet, A. Toussaint, K. Kulicke, D. Häussinger, M. Neuburger, S. Schaffner, S. Kaiser, A. Pfaltz*
Chemistry – Eur. J. 2008, 14, 8530-8539

The structure of monoamine oxidase from Aspergillus niger provides a molecular context for improvements in activity obtained by directed evolution
K. E. Atkin, R. Reiss, V. Koehler, K. R. Bailey, S. Hart, J. P. Turkenburg, N. J. Turner, A. M. Brzozowski*, G. Grogan*
J. Mol. Biol. 2008, 384, 1218-1231


2006

Kinetic resolution of diols and pyridyl alcohols by Cu (II)(borabox)-catalyzed acylation
C. Mazet, S. Roseblade, V. Köhler, A. Pfaltz*
Org. Lett. 2006, 8, 1879-1882

Synthesis of boron-bridged anionic C2-symmetric bisoxazolines and their application in asymmetric catalysis
C. Mazet, V. Köhler, S. Roseblade, A. Toussaint, A. Pfaltz*
Chimia 2006, 60, 195-198


2005

Chiral boron-bridged bisoxazolines: Readily available anionic ligands for asymmetric catalysis
C. Mazet, V. Köhler, A. Pfaltz*
Angew. Chem. Int. Ed. 2005, 44, 4888-4891