University of Basel

Department
of Chemistry

Research Group Koehler

Publications

NSPs: chromogenic linkers for fast, selective, and irreversible cysteine modification
Y. Hua, Z. Zou, A. Prescimone, T. R. Ward, M. Mayor, V. Köhler*
Chem. Sci., 2024, DOI: 10.1039/D4SC01710B

Highly sensitive single-molecule detection of macromolecule ion beams
M. Strauß, A. Shayeghi, M.F. X. Mauser, P. Geyer, T. Kostersitz, J. Salapa, O. Dobrovolskiy, S. Daly, J. Commandeur, Y. Hua, V. Köhler, M. Mayor, J. Benserhir, C. Bruschini, E. Charbon, M. Castaneda, M. Gevers, R. Gourgues, N. Kalhor, A. Fognini, M. Arndt*
Science Advances 2023, 9 (48)

Giving the Green Light to Photochemical Uncaging of Large Biomolecules in High Vacuum
Y. Hua, M. Strauss, S. Fisher, M. F. X. Mauser, P. Manchet, M. Smacchia, P. Geyer, A. Shayeghi, M. Pfeffer, T. H. Eggenweiler, S. Daly, J. Commandeur, M. Mayor, M. Arndt,* T. Šolomek,* V. Köhler*
ACS Au 2023, 3, 10, 2790–2799

Artificial Metalloenzyme-Catalyzed Enantioselective Amidation via Nitrene Insertion in Unactivated C(sp3)–H Bonds
K. Yu, Z. Zou, N. V. Igareta, R. Tachibana, J. Bechter, V. Köhler, D. Chen, T. R. Ward*
J. Am. Chem. Soc. 2023,145, 30, 16621–16629

Superconducting quantum detectors and single photon charge control for mass spectrometry
M. Strauß, A. Shayeghi, M. Mauser, P. Manchet, M. Smacchia, J. Salapa, T. Kostersitz, P. Geyer, S. Daly, J. Commandeur, Y. Hua, A. Di Silvestro, M. Mayor, V. Köhler, J. Benserhir, C. Bruschini, E. Charbon, M. Castaneda, M. Gevers, R. Gourgues, N. Kalhor, A. Fognini, M. Arndt
Proc. SPIE 12447, Quantum Sensing, Imaging, and Precision Metrology, 124470I (8 March 2023)

Enantioselective Allylation of Stereogenic Nitrogen Centers
S. Zaitseva, A. Prescimone, V. Köhler*
Org. Lett. 2023, 25, 10, 1649–1654

Otto Stern’s Legacy in Quantum Optics: Matter Waves and Deflectometry
S. Gerlich, Y. Y. Fein, A. Shayeghi, V. Köhler, M. Mayor, M. Arndt*
Molecular Beams in Physics and Chemistry (Eds. B. Friedrich, H. Schmidt-Böcking), Springer, Cham., 2021, pp. 547-573

Matter-wave interference and deflection of tripeptides decorated with fluorinated alkyl chains
J. Schätti, V. Köhler, M. Mayor, Y. Y. Fein, P. Geyer, L. Mairhofer, S. Gerlich, M. Arndt*
J. Mass Spectrom. 2020, 55, e4514

Neutralization of insulin by photocleavage under high vacuum
J. Schätti, M. Kriegleder, M. Debiossac, M. Kerschbaum, P. Geyer, M. Mayor, M. Arndt*, V. Köhler*
Chem. Commun. 2019, 55, 12507-12510

Artificial Metalloenzymes: Reaction Scope and Optimization Strategies
F. Schwizer, Y. Okamoto, T. Heinisch, Y. Gu, M. M. Pellizzoni, V. Lebrun, R. Reuter, V. Köhler, J. C. Lewis*, T. R. Ward*
Chem. Rev. 2018, 118, 142-231

Pushing the mass limit for intact launch and photoionization of large neutral biopolymers
J. Schätti, P. Rieser, U. Sezer, G. Richter, P. Geyer, G. G. Rondina, D. Häussinger, M. Mayor, A. Shayeghi, V. Köhler*, M. Arndt*
Commun. Chem. 2018, 1, 93

Tailored photocleavable peptides: fragmentation and neutralization pathways in high vacuum
M. Debiossac, J. Schätti, M. Kriegleder, P. Geyer, A. Shayeghi, M. Mayor, M. Arndt*, V. Köhler*
Phys. Chem. Chem. Phys. 2018, 20, 11412-11417

Tailoring the volatility and stability of oligopeptides
J. Schätti, U. Sezer, S. Pedalino, J. Cotter, M. Arndt*, M. Mayor, V. Köhler*
J. Mass Spectrom. 2017, 52, 550-556

An NAD(P)H-dependent artificial transfer hydrogenase for multienzymatic cascades
Y. Okamoto, V. Köhler, T. R. Ward*
J. Am. Chem. Soc. 2016, 138, 5781-5784

Efficient in situ regeneration of NADH mimics by an artificial metalloenzyme
Y. Okamoto, V. Köhler, C. E. Paul, F. Hollmann, T. R. Ward*
ACS Catal. 2016, 6, 3553-3557

Upregulation of an artificial zymogen by proteolysis
Z. Liu, V. Lebrun, T. Kitanosono, H. Mallin, V. Köhler, D. Häussinger, D. Hilvert, S. Kobayashi, T. R. Ward*
Angew. Chem. Int. Ed. 2016, 55, 11587-11590

Cascade Reactions
M. Dürrenberger, V. Köhler, Y. M. Wilson, D. Ghislieri, L. Knörr, N. J. Turner, T. R. Ward
Practical Methods for Biocatalysis and Biotransformations 3 (Eds. J. Whittall, P. W. Sutton, W. Kroutil),  J. Wiley & Sons Ltd., Chichester, 2016, pp. 213-252

Artificial metalloenzymes for the diastereoselective reduction of NAD+ to NAD2H
T. Quinto, D. Häussinger, V. Köhler, T. R. Ward*
Org. Biomol. Chem. 2015, 13, 357-360

Artificial concurrent catalytic processes involving enzymes
V. Köhler*, N. J. Turner*
Chem. Commun. 2015, 51, 450-464

Improving the catalytic performance of an artificial metalloenzyme by computational design
T. Heinisch, M. Pellizzoni, M. Dürrenberger, C. E. Tinberg, V. Köhler, J. Klehr, D. Häussinger, D. Baker*, T. R. Ward*
J. Am. Chem. Soc. 2015, 137, 10414-10419

Expanding the chemical diversity in artificial imine reductases based on the biotin–streptavidin technology
T. Quinto, F. Schwizer, J. M. Zimbron, A. Morina, V. Köhler, T. R. Ward*
ChemCatChem 2014, 6, 1010-1014

Recent trends in biomimetic NADH regeneration
T. Quinto, V. Köhler, T. R. Ward*
Top. Catal. 2014, 57, 321-331

An artificial imine reductase based on the ribonuclease S scaffold
M. Genz, V. Köhler, M. Krauss, D. Singer, R. Hoffmann, T. R. Ward, N. Sträter*
ChemCatChem 2014, 6, 736-740

Genetic optimization of the catalytic efficiency of artificial imine reductases based on biotin–streptavidin technology
F. Schwizer, V. Köhler, M. Dürrenberger, L. Knörr, T. R. Ward*
ACS Catal. 2013, 3, 1752-1755

Synthetic cascades are enabled by combining biocatalysts with artificial metalloenzymes
V. Köhler, Y. Wilson, M. Dürrenberger, D. Ghislieri, E. Churakova, T. Quinto, L. Knörr, D. Häussinger, F. Hollmann*, N. Turner*, T. R. Ward*
Nat. Chem. 2013, 5, 93-99

Selective Oxidation
V. Köhler, B. Groenendaal, K. R. Bailey, A. Znabet, J. Raferty, M. Helliwell, N. J. Turner, K. Geitner, U. T. Bornscheuer, G. de Gonzalo
Practical Methods for Biocatalysis and Biotransformations 2 (Eds. J. Whittall, P. W. Sutton), J. Wiley & Sons Ltd., Chichester, 2012, pp. 181-202

Chimeric self-sufficient P450cam-RhFRed biocatalysts with broad substrate scope
A. Robin, V. Köhler, A. Jones, A. Ali, P. P. Kelly, E. O'Reilly, N. J. Turner, S. L. Flitsch*
Beilstein J. Org. Chem. 2011, 7, 1494-1498

Cytochromes P450 as useful biocatalysts: addressing the limitations
E. O'Reilly, V. Köhler, S. L. Flitsch*,  N. J. Turner*
Chem. Commun. 2011, 47, 2490-2501

OsO4⋅ Streptavidin: A Tunable Hybrid Catalyst for the Enantioselective cis‐Dihydroxylation of Olefins
V. Köhler, J. Mao, T. Heinisch, A. Pordea, A. Sardo, Y. M. Wilson, L. Knörr, M. Creus, J. C. Prost, T. Schirmer*, T. R. Ward*
Angew. Chem. Int. Ed. 2011, 50, 10863-10866

Highly stereoselective synthesis of substituted prolyl peptides using a combination of biocatalytic desymmetrization and multicomponent reactions
A. Znabet, E. Ruijter, F. J. de Kanter, V. Köhler, M. Helliwell, N. J. Turner, R. V. Orru*
Angew. Chem. Int. Ed. 2010, 49, 5289-5292

Protein-based hybrid catalysts — design and evolution
V. Köhler, Y. M. Wilson, C. Lo, A. Sardo, T. R. Ward*
Curr. Opin. Biotechnol. 2010, 21, 744-752

Enantioselective biocatalytic oxidative desymmetrization of substituted pyrrolidines
V. Köhler, K. R. Bailey, A. Znabet, J. Raftery, M. Helliwell, N. J. Turner*
Angew. Chem. Int. Ed. 2010, 49, 2182-2184

Chiral boron‐bridged bisoxazoline (Borabox) ligands: Structures and reactivities of Pd and Cu complexes
V. Köhler, C. Mazet, A. Toussaint, K. Kulicke, D. Häussinger, M. Neuburger, S. Schaffner, S. Kaiser, A. Pfaltz*
Chemistry – Eur. J. 2008, 14, 8530-8539

The structure of monoamine oxidase from Aspergillus niger provides a molecular context for improvements in activity obtained by directed evolution
K. E. Atkin, R. Reiss, V. Koehler, K. R. Bailey, S. Hart, J. P. Turkenburg, N. J. Turner, A. M. Brzozowski*, G. Grogan*
J. Mol. Biol. 2008, 384, 1218-1231

Kinetic resolution of diols and pyridyl alcohols by Cu (II)(borabox)-catalyzed acylation
C. Mazet, S. Roseblade, V. Köhler, A. Pfaltz*
Org. Lett. 2006, 8, 1879-1882

Synthesis of boron-bridged anionic C2-symmetric bisoxazolines and their application in asymmetric catalysis
C. Mazet, V. Köhler, S. Roseblade, A. Toussaint, A. Pfaltz*
Chimia 2006, 60, 195-198

Chiral boron-bridged bisoxazolines: Readily available anionic ligands for asymmetric catalysis
C. Mazet, V. Köhler, A. Pfaltz*
Angew. Chem. Int. Ed. 2005, 44, 4888-4891

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